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1.
Pest Manag Sci ; 73(9): 1921-1926, 2017 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-28233443

RESUMO

BACKGROUND: Nanotechnology has recently allowed the production of formulations for controlled release of active ingredients. In the present study, the electrospinning technique was used to produce nanoscale dispensers for attract-and-kill strategies. Non-woven nanofibres containing insecticide (cypermethrin) and (E)-8,(Z)-8-dodecenyl acetate and (Z)-8-dodecanol (0.87 mg L-1 ), the main components of Grapholita molesta (Lepidoptera: Tortricidae) (Busck) pheromone, were evaluated in laboratory experiments. Male electroantennographic (EAG) responses and mortality (tarsal-contact and attract-and-kill behavioural cages) bioassays were performed for nanofibres (with and without insecticide) exposed for different periods (21, 42, 63 and 84 days) in controlled and non-exposed conditions. RESULTS: There were no significant differences in G. molesta male EAG responses based on the time of exposure within treatments. Nanofibres with pheromone only and with pheromone plus insecticide elicited equal EAG responses. Mortality in tarsal-contact bioassays was greater than 87% after exposure for 84 days. In the attract-and-kill bioassays, mortality ranged from 28.4 to 56.6%, although no difference was observed on insect mortalities over time (24, 48 and 72 h). CONCLUSION: Incorporation of cypermethrin in nanofibres did not interfere with G. molesta attractiveness. Both aspects of the strategy, the attractant and killing effects, were recorded using innovative nanofibres, and long-term effects suggest a controlled release of pheromone and insecticide. © 2017 Society of Chemical Industry.


Assuntos
Bioensaio/instrumentação , Laboratórios , Lepidópteros/efeitos dos fármacos , Nanotecnologia/instrumentação , Feromônios/farmacologia , Animais , Masculino
2.
Eur J Pharm Sci ; 84: 70-6, 2016 Mar 10.
Artigo em Inglês | MEDLINE | ID: mdl-26775870

RESUMO

Nanotechnology strategies have been used for delivery and controlled release of antimicrobial drugs. Electrospun nanofibers can be versatile vehicles to incorporate antimicrobials. In this work, poly-ε-caprolactone nanofibers functionalized with ketoconazole were produced by electrospinning and tested against filamentous fungi. Ketoconazole-free nanofibers were produced as controls. Functionalized nanofibers showed antifungal activity against Aspergillus flavus, A. carbonarius, A. niger, Aspergillus sp. A29, Fusarium oxysporum and Penicillium citrinum by agar diffusion test. Inhibitory zones ranging from 6 to 44mm were observed, this larger inhibition was against A. flavus. The nanofibers were incubated in different simulant solutions to evaluate the ketoconazole release, which was only detected in the solution containing 5% (v/v) Tween 20. Electron microscopy images showed the nanofibers with ketoconazole presented mean diameters of 526nm, and the degradation of the nanofiber structures could be observed by electron microscopy after incubation in simulant solution. Infrared and thermal analyses indicated that ketoconazole was dispersed without chemical interactions with the polycaprolactone matrix. These results suggest that polycaprolactone nanofibers incorporating ketoconazole may be an interesting alternative to control pathogenic fungi.


Assuntos
Antifúngicos/administração & dosagem , Aspergillus/efeitos dos fármacos , Fusarium/efeitos dos fármacos , Cetoconazol/administração & dosagem , Nanofibras/administração & dosagem , Penicillium/efeitos dos fármacos , Antifúngicos/química , Liberação Controlada de Fármacos , Cetoconazol/química , Nanofibras/química , Nanotecnologia/métodos , Poliésteres/administração & dosagem , Poliésteres/química , Tecnologia Farmacêutica/métodos
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